Immunophilin family
Witryna26 mar 2004 · Search life-sciences literature (Over 39 million articles, preprints and more) Witryna28 gru 2024 · Moreover, FKBP8 is part of a large immunophilin family of proteins. Interestingly, in addition to FKBP8, several cyclophilins (additional members of the …
Immunophilin family
Did you know?
WitrynaEncodes a member of the FKBP-type immunophilin family that functions as a histone chaparone. Binds to 18S rDNA and represses its expression. FKBP53 FK506 … WitrynaEach immunophilin family has been structurally characterised with a variety of small molecule ligands, principally immunosuppressive drugs and their analogues and an …
WitrynaFK506-binding proteins (FKBP) belong to the immunophilin family and are best known for their ability to enable the immunosuppressive properties of FK506 and rapamycin. For rapamycin, this is achieved by inducing inhibitory ternary complexes with the kinase mTOR. The essential accessory protein for this gain-of-function was thought to be … WitrynaThe AP2/ERF family is an important class of transcription factors involved in plant growth and various biological processes. ... (CYP) belongs to the immunophilin family and has peptidyl-prolyl ...
Witryna9 lip 2008 · The immunophilin superfamily is classified into three major subfamilies, including the cyclosporin A (CsA) binding proteins (cyclophilins or Cyps) , FK506 … In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases (PPI) that catalyze the interconversion between the cis and trans isomers of peptide bonds containing the amino acid proline (Pro). They are chaperone molecules that generally assist in the proper folding of diverse "client" proteins. Immunophilins are traditionally classified into two families that differ in sequence and biochemical characteristics. These two families are: "cyclosporin-binding cyclophil…
WitrynaEach immunophilin family has been structurally characterised with a variety of small molecule ligands, principally immunosuppressive drugs and their analogues and an …
Witryna1 mar 2006 · Table of Contents 2006 - 59 (3) Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus. March 01, 2006 [ MEDLINE Abstract] A new … on this day in history calendar 2002WitrynaCurrent data suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby … iosh plan do check actWitrynaThe FKBP s, or FK506 binding proteins, constitute a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino … iosh presidential teamWitryna31 paź 2006 · Immunophilins are chaperones that may also exhibit peptidylprolyl isomerase (PPIase) activity. This review summarizes our knowledge of the two largest families of immunophilins, namely cyclophilin and FK506-binding protein, and a novel chimeric dual-family immunophilin, named FK506- and cyclosporin-binding protein … on this day in history calendar 2005WitrynaInterests in Science: Teaching, Academia, Basic Research, Health and Nutrition, Pharmaceutical R&D Career achievements in science and medical research leading … iosh platformWitrynaThis review focuses on molecular characteristics of the canonical and non-canonical immunophilin family members from human and Plasmodium falciparum and P. … on this day in history calendar 2001Witryna2 paź 2007 · In Arabidopsis, genes encoding 52 putative immunophilins have been identified: 23 FKBPs and 29 CYPs ().This group is by far the largest immunophilin … iosh proactive safety