Cisplatin cystenyl glycine conjugate
WebNational Center for Biotechnology Information WebStudies of placental DNA adducts have mainly focused on PAH-compounds (e.g. BP and its derivates) or AFB1, because they are metabolized by CYP1A1 found in human placenta. It remains to be studied whether any of the substrates of other CYP enzymes are metabolized in human placenta to reactive metabolites which form DNA adducts.
Cisplatin cystenyl glycine conjugate
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WebMar 1, 2009 · In a series of papers, Hanigan and coauthors reported that the Pt-cysteine S-conjugate was converted to a toxic, highly reactive Pt-thiol by any of the several … WebAug 28, 2009 · Purpose The mechanisms for cisplatin-induced renal cell injury have been the focus of intense investigation for many years with a view to provide a more effective and convenient form of nephroprotection. BNP7787 (disodium 2,2′-dithio-bis ethane sulfonate; dimesna, Tavocept™), is a water-soluble disulfide investigational new drug that is …
WebMetabolism of glutathione conjugate and the cystenyl-glycine conjugate occurs extracellularly, the cysteine conjugate metabolized intracellularly to reactive thiol by cysteine-S conjugate-lyase. The osmotic stress response could be affecting any of several steps in this pathway2, thus help to reverse the toxic effect of Cisplatin. WebCisplatin is a potent antitumor agent currently used in the treatment of germ cell tumors, head and neck tumors, cervical cancer, and as a salvage treatment for other solid tumors …
Web10.1007/s00280-010-1333-x Abstract Purpose: Dekant has proposed that gamma-glutamyl transpeptidase (GGT), aminopeptidase N (APN) and cysteine-conjugate-β-lyase (CCBL) … WebCisplatin is nephrotoxic. The mechanism underlying this organ-specific toxicity is unknown. We hypothesize that cisplatin is metabolized via a γ -glutamyl transpeptidase (GGT) and cysteine S -conjugate β -lyase-dependent pathway that has been shown to activate several haloalkenes to nephrotoxins.
WebJan 30, 2024 · Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of malignancies due to its high efficacy and low cost. ... The resulting GSH-conjugates are cleaved into a cysteinyl-glycine-conjugate by gamma glutamyltranspeptidase which is localized on the surface of the kidney proximal tubule …
WebNov 1, 2001 · The cysteine-conjugates are taken up into the cell and converted to a reactive thiol by either cysteine-conjugate β-lyase or S-oxidase. ... cisplatin-cysteinyl-glycine-conjugates, and cisplatin-cysteine-conjugates are all more toxic to proximal tubule cells than cisplatin. 25 We have also shown that inhibition of cysteine-conjugate β-lyase by ... green things landscapingWebwww.ncbi.nlm.nih.gov green things in tucson azWebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. Department of Health and Human Services. green things lawn care clearwaterWebJul 8, 2024 · Previous studies have supported the existence of a mercapturic acid metabolite of cisplatin called NAC-1 ( Figure 4 a ), 9 a negatively charged N-acetylcysteine S-conjugate that acts as a … green things nursery orofino idahoWebAug 1, 2007 · Cisplatin/cysteinyl-glycine complexes were also found in the supernatant of GGT-transfected cisplatin-resistant HeLa cells ; this finding seems to indicate a poor membrane permeability of thiol/cisplatin complexes. It shouldalso be considered that cysteinyl-glycine reacts with cisplatin, approximately fivefold faster than GSH . fnb slow lounge benefitsWebThe first step is the conjugation to glutathione, followed by the cleavage by GGT to a cysteinyl-glycine conjugate, the cleavage by aminopeptidase to a cysteine S … green things nurseryWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … fnb single facility